| Company | Rank | 2010 rev (mUSD) | 2009 rev (mUSD) | rev change (%) | 2010 inc (mUSD) | 2009 inc (mUSD) | inc change (%) | NPM (%) | 2009 eq (mUSD) | pipeline | financial statement | top product (revenue) | comment | Founded | acquisition(s) | HQ & research | type |
| Amgen | 1 | 14660 | 14351 | 2 | 4627 | 4605 | 0 | 31 |   | Sensipar, Aranesp, Denosumab, Motesanib, Panitumumab link |   | Neulasta | world's largest biotech company | 1980 | Immunex (1980-2002) | CA | pharma, protein drugs |
| Gilead Sciences | 2 | 7949 | 7011 | 13 | 2901 | 2635 | 10 | 39 |   | link |   | Atripla |   | 1987 |   | CA, Foster City | pharma, small molecule anti HIV drugs |
| Celgene | 2 | 3625 | 2689 | 34 | 880 | 776 | 13 | 35 | 4395 | link |   | Revlimid |   | 1986 | Abraxis BioScience (2010) | NJ, Summit | pharma, small molecule anticancer drugs |
| Cephalon | 2 | 2761 | 2151 | 28 | 425 | 342 | 24 | 19 | 2262 | link |   | Provigil |   | 1987 |   | PA | small molecule neural drugs |
| Novozymes | 2 |   | 1494 |   |   | 211 |   | 14 | 1031 |   |   |   | link | 1924 |   | Denmark / CA, Davis | biotech, enzymes |
| Hoffmann-La Roche | 3 |   | 52831 |   |   | 8040 |   | 15 | 7608 | link |   | Avastin | world's second largest enzyme manufacturer | 1896 | Genentech (1976-2009), Genencor (1982-2005), Danisco (1872-2011) | CA, San Francisco / Palo Alto | pharma / biotech, enzymes |
| Sanofi-Aventis | 3 |   | 38917 |   |   | 8246 |   | 21 |   |   |   | Lantus |   | 1863 | Genzyme (1981-2011) | Paris | pharma, small molecule drugs |
| Merck KGaA | 3 |   | 10207 |   |   | 483 |   | 5 | 12465 |   |   | Rebif |   | 1668 | Serono (1906-2006), Millipore (1954-2010) | Geneva / Darmstadt |   |
| UCB | 3 |   | 3834 |   |   | 676 |   | 18 | 5817 | link |   | Keppra |   | 1928 |   | Belgium | small molecule neural drugs |
| Novo Nordisk | 3 |   | 1535 |   |   | 324 |   | 21 |   | link | link | Novolog | link | 1924 |   | Bagsvaerd | pharma, insulin |
| Boehringer Ingelheim | 3 |   |   |   |   |   |   |   |   | link |   | Spiriva |   | 1885 |   | Germany |   |
| Nycomed | 3 |   |   |   |   |   |   |   |   | link |   | Pantozol |   | 1874 |   |   |
| Actelion | 3 |   |   |   |   |   |   |   |   | link |   | Tracleer |   | 1997 |   | Switzerland | small molecule endothelial drugs |
| Regeneron | 3 |   |   |   |   |   |   |   |   |   |   | Rilonacept |   | 1988 |   | NY, Tarrytown | pharma |
| Lonza | 3 |   |   |   |   |   |   |   |   |   |   |   |   | 1897 |   | Basel |   |
| Johnson & Johnson | 4 |   | 61897 |   |   | 12266 |   | 20 |   | link |   | Remicade |   | 1886 | Centocor (1979-1999), Alza (1968-2001) | NJ, New Brunswick | pharma |
| Astellas Pharma | 4 |   |   |   |   |   |   |   |   |   |   | Prograf |   | 1894 | OSI Pharmaceuticals (1983-2010) | Tokyo |   |
| Takeda Pharmaceuticals | 5 |   | 17473 |   |   | 3549 |   | 20 | 25284 |   |   | Actos |   | 1781 |   | Osaka |   |
| CSL | 5 |   | 4406 |   |   | 1041 |   | 24 | 4168 | link |   | Gardasil |   | 1916 |   | Australia |   |
| Daiichi Sankyo | 5 |   |   |   |   |   |   |   |   |   |   | Benicar |   | 1899 |   | Tokyo |   |
| Eisai | 5 |   |   |   |   |   |   |   |   |   |   | Aricept |   | 1936 |   | Tokyo |   |
| Associated British Foods | 6 |   | 14357 |   |   | 557 |   | 4 | 7366 |   |   |   |   | 1935 |   | London |   |
| DSM | 6 |   | 10188 |   |   |   |   |   |   |   |   |   |   | 1902 |   | Netherlands |   |
| Procter & Gamble | 6 |   |   |   |   |   |   |   |   |   |   | Actonel | link | 1837 |   | OH, Cincinatti |   |
| Endo Pharmaceuticals | 6 |   |   |   |   |   |   |   |   |   |   |   |   | 1997 |   | PA | pharma, generic drugs |
| Leo Pharma | 6 |   |   |   |   |   |   |   |   |   |   |   |   | 1908 |   | Denmark | pharma |
| Carlsberg | 6 |   |   |   |   |   |   |   |   |   |   |   |   | 1847 |   | Denmark | brewery |
| BASF | 7 |   | 66793 |   |   | 1858 |   | 3 | 23028 |   |   |   | largest chemical corporation in the world by revenue and market cap | 1865 |   | Ludwigshafen | chemical (e.g. agricultural small molecule drugs) |
| Teva Pharmaceuticals | 7 |   | 3868 |   |   | 557 |   | 14 | 5349 |   |   | Copaxone |   | 1901 |   | Israel | pharma, generic drugs |
| Sigma Aldrich | 7 |   |   |   |   |   |   |   |   |   |   |   |   | 1934 |   |   | equipment and chemicals |
| Becton Dickinson | 7 |   |   |   |   |   |   |   |   |   |   |   | link |   |   |   |   |
| GE Healthcare | 7 |   |   |   |   | 11440 |   |   |   |   |   | Omnipaque |   | 1892 | Amersham (1946-2004) |   | equipment and chemicals |
| Siemens Healthcare | 7 |   |   |   |   |   |   |   |   |   |   |   |   |   | Shared Medical Systems Corporation (-2000) |   |   |
| Philips Healthcare | 7 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Thermo Fisher Scientific | 7 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Otsuka Pharmaceutical | 7 |   |   |   |   |   |   |   |   |   |   | Abilify |   | 1964 |   | Tokyo |   |
| Pfizer | 8 |   | 50009 |   |   | 8619 |   | 17 |   | link | link | Lipitor | link | 1849 | Wyeth (1860-2009), King Pharmaceuticals (1994-2010, incl. Alpharma) | NY, NYC | pharma, small molecule drugs |
| Novartis | 8 |   | 45103 |   |   | 9937 |   | 22 |   | link | link | Diovan | link | 1758 | Alcon (1945-2010) | Basel |   |
| GlaxoSmithKline | 8 |   | 43986 |   |   | 6258 |   | 14 |   |   |   | Seretide (EU), Advair (US) | link | 1830 |   | England / US |   |
| Bayer | 8 |   | 41067 |   |   | 1791 |   | 4 |   |   |   | Betaferon | link | 1863 | Schering AG (1851-2006) | Leverkusen | pharma |
| AstraZeneca | 8 |   | 32804 |   |   | 7777 |   | 24 |   |   |   | Crestor | link | 1913 | MedImmune (1988-2007) | London / Sweden |   |
| Abbott Laboratories | 8 |   | 30765 |   |   | 4684 |   | 15 |   |   |   | Humira | link | 1888 | Solvay Pharmaceutical (1863-2010) | IL, Chicago | pharma, biologics and small molecule drugs |
| Merck & Co. | 8 |   | 27428 |   |   | 8596 |   | 31 |   |   |   | Singulair | link | 1917 | Schering-Plough (1851-2009) | NJ |   |
| Eli Lilly | 8 |   | 21836 |   |   | 5028 |   | 23 | 9524 | link |   | Zyprexa | link | 1876 | ImClone Systems (1984-2008) | IN, Indianapolis | pharma, insulin and antidepressants |
| Bristol Myers Squibb | 8 |   | 18808 |   |   | 3321 |   | 18 |   |   |   | Plavix | link | 1858 |   | NY, NYC |   |
| Baxter International | 8 |   | 12562 |   |   | 2205 |   | 18 |   |   |   | Advate | link |   |   | IN, Deerfield |   |
| Biogen Idec | 8 |   | 4377 |   |   | 960 |   | 22 |   |   |   | Avonex | link | 1978 |   | MA, Weston / CA, San Diego | pharma, biologics / antibodies |
| Lundbeck | 8 |   |   |   |   |   |   |   |   |   |   | Cipralex (EU), Lexapro (US) |   | 1915 |   | Denmark |   |
| Forest Laboratories | 8 |   |   |   |   | 614 |   |   |   |   |   | Lexapro (US), Cipralex (EU) | link |   |   |   |   |
| Shire plc | 8 |   |   |   |   |   |   |   |   |   |   | Adderall | link | 1986 |   |   |   |
| Allergan | 9 |   |   |   |   |   |   |   |   |   |   | Botox |   | 1948 |   | CA, Irvine |   |
| Monsanto | 9 |   |   |   |   | 1073 |   |   |   |   |   |   | link | 1901 |   | MO | biotech, agricultural |
| Cargill/Degussa | 9 |   |   |   |   |   |   |   |   |   |   |   | link | 1865 |   | MN |   |
| Dow Chemical | 9 |   |   |   |   |   |   |   |   |   |   |   | Napalm, Agent Orange, Bhopal; 2nd largest global chem corp by rev | 1897 |   |   | chemical |