| Company | Product | Generic Name | 2010 rev (mUSD) | 2010 Rank | Patent Numbers | Expiration of first patent (US) | ATC code | type of drug | drug target |
| Pfizer | Lipitor | Atorvastatin | 10733 | 1 | 4,681,893 | 2011.01.01 | C10 | small molecule drug | HMG CoA reductase inhibitor |
| GlaxoSmithKline | Seretide (EU), Advair (US) | Fluticasone/salmeterol | 7900 | 2 | 0 | 2011.01.01 | R03 | small molecule drug (corticosteroid) | 0 |
| Bristol Myers Squibb | Plavix | Clopidogrel | 6700 | 4 | 4,847,265 | 2011.01.01 | B01 (antithrombotic) | small molecule drug | GPCR inhibitor (glycoprotein IIb/IIIa pathway inhibitor) |
| Novartis | Diovan | Valsartan | 6053 | 7 | 5,399,578 | 2012.01.01 | C09 | small molecule drug | 0 |
| Novartis | Co-Diovan | Hydrochlorothiazide | 6053 | 7 | 0 | 2012.01.01 | C03 (Diuretic) | small molecule drug | 0 |
| Hoffmann-La Roche | Herceptin | Trastuzumab | 5700 | 9 | 5,399,578 | 2012.01.01 | C09 | protein (mAb) | CD340 |
| Eli Lilly | Zyprexa | Olanzapine | 5030 | 11 | 5,229,382 | 2011.01.01 | N05 (Psycholeptic) | small molecule drug | 0 |
| Merck & Co. | Singulair | Montelukast | 5000 | 12 | 5,565,473 | 2012.01.01 | R03 | small molecule drug | leukotriene receptor antagonist |
| Takeda Pharmaceuticals | Actos | Pioglitazone | 4200 | 19 | 4,687,777 | 2011.01.01 | A10 (Diabetes) | small molecule drug (racemate) | 0 |
| AstraZeneca | Seroquel | Quetiapine | 4100 | 20 | 4,879,288 | 2012.01.01 | N05 (Psycholeptic) | small molecule drug (thiazepine) | GPCR (serotonin receptor) inhibitor |
| Sanofi-Aventis | Lovenox | Enoxaparin | 3700 | 22 | 5,389,618 | 2012.01.01 | B01 (antithrombotic) | small molecule drug (heparin) | 0 |
| Amgen | Enbrel | Etanercept | 3274 | 26 | 0 | 2012.10.23 | L04 (Immunosuppressant) | protein (mAb) | TNF |
| Forest Laboratories | Lexapro (US), Cipralex (EU) | Escitalopram | 2300 | 35 | 6,916,941 | 2012.03.01 | N06 (Psychoanaleptic) | small molecule drug (enantiomer) | 0 |
| Pfizer | Viagra | Sildenafil | 1928 | 40 | 5,250,534 | 2012.01.01 | G04BE (erectile dysfunction) | small molecule drug | 0 |
| Pfizer | Xalatan/Xalacom | 0 | 1749 | 42 | 0 | 2011.01.01 | 0 | 0 | 0 |
| Novartis | Zometa | Zoledronic acid | 1511 | 49 | 4,939,130 | 2012.01.01 | M05 | 0 | 0 |
| Lundbeck | Cipralex (EU), Lexapro (US) | Escitalopram | 1500 | 50 | RE34712 | 2011.03.01 | N06 (Psychoanaleptic) | small molecule drug | 0 |
| Pfizer | Detrusitol/Detrol | Tolterodine | 1013 | 57 | 5,382,600 | 2012.01.01 | G04 (Urological) | small molecule drug | 0 |