Company	product name	Generic name	2010 rev (mUSD)	2009 rev (mUSD)	Rev Change	2010 Rank	2009 Rank	Rank Change	YoY rev growth (%)	Patent Numbers	Expiration of first patent (US)	Expiration of last patent (US)	Patent Expiration (EU)	ATC code	type of drug	drug target	type of drug (function)	PDB	Company
Pfizer	Lipitor	Atorvastatin	10733	11434		1	1	0	0	4,681,893	2011.01.01			C10	small molecule drug	HMG CoA reductase inhibitor	lipid regulator		Pfizer
GlaxoSmithKline	Seretide (EU), Advair (US)	Fluticasone/salmeterol	7900	8098		2	4	2	0		2011.01.01			R03	small molecule drug (corticosteroid)		asthma		GlaxoSmithKline
Hoffmann-La Roche	Avastin	Bevacizumab	6800	5013		3	11	8	0	6,054,297	2018			L01 (Antineoplastic)	protein (mAb)				Hoffmann-La Roche
Bristol Myers Squibb	Plavix	Clopidogrel	6700	9059		4	2	-2	0	4,847,265	2011.01.01			B01 (antithrombotic)	small molecule drug	GPCR inhibitor (glycoprotein IIb/IIIa pathway inhibitor)			Bristol Myers Squibb
Hoffmann-La Roche	MabThera / Rituxan	Rituximab	6700	4681		4	13	9	0		2015			L01 (Antineoplastic)	protein (mAb)	CD20			Hoffmann-La Roche
Abbott Laboratories	Humira	Adalimumab	6500	5032		6	10	4	0	6,090,382	2016			L04 (Immunosuppressant)	protein (mAb)	TNFalpha			Abbott Laboratories
Novartis	Diovan	Valsartan	6053	3912		7	19	12	0	5,399,578	2012.01.01			C09	small molecule drug				Novartis
Novartis	Co-Diovan	Hydrochlorothiazide	6053	2617		7	33	26	1		2012.01.01			C03 (Diuretic)	small molecule drug				Novartis
AstraZeneca	Crestor	Rosuvastatin	5700	5383		9	8	-1	0	RE37314	2016			C10	small molecule drug				AstraZeneca
Hoffmann-La Roche	Herceptin	Trastuzumab	5700	3890		9	20	11	0	5,399,578	2012.01.01			C09	protein (mAb)	CD340			Hoffmann-La Roche
Eli Lilly	Zyprexa	Olanzapine	5030	5295		11	9	-2	0	5,229,382	2011.01.01			N05 (Psycholeptic)	small molecule drug				Eli Lilly
AstraZeneca	Nexium	Esomeprazole	5000	8236		12	3	-9	0		2015			A02 (Antacid)	small molecule drug	H+/K+-ATPase inhibitor (gastric)			AstraZeneca
Merck & Co.	Singulair	Montelukast	5000	4986		12	12	0	0	5,565,473	2012.01.01			R03	small molecule drug	leukotriene receptor antagonist			Merck & Co.
Amgen	Neulasta	Pegfilgrastim (PEGylated filgrastim)	4800	3678		14	22	8	0		2015		2015	L03 (Immunostimulant)	protein (insulin)	growth factor / immunostimulant / cytokine (granulocytes)			Amgen
Amgen	Neupogen	Filgrastim	4800	1322		14	83	69	2		2013					granulocytes	growth factor		Amgen
Sanofi-Aventis	Lantus	Insulin Glargine	4700	3968		16	18	2	0	6,100,376	2009			A10 (Diabetes)	protein (insulin)				Sanofi-Aventis
Johnson & Johnson	Remicade	Infliximab	4600	5453		17	7	-10	0		2018			L04 (Immunosuppressant)	protein (mAb)	TNFalpha			Johnson & Johnson
Novartis	Gleevec (US) / Glivec (EU)	Imatinib	4265	3419		18	24	6	0					L01 (Antineoplastic)	small molecule drug				Novartis
Takeda Pharmaceuticals	Actos	Pioglitazone	4200	4116		19	16	-3	0	4,687,777	2011.01.01			A10 (Diabetes)	small molecule drug (racemate)				Takeda Pharmaceuticals
AstraZeneca	Seroquel	Quetiapine	4100	5974		20	5	-15	0	4,879,288	2012.01.01			N05 (Psycholeptic)	small molecule drug (thiazepine)	GPCR (serotonin receptor) inhibitor			AstraZeneca
Boehringer Ingelheim	Spiriva	Tiotropium	3800	3499		21	23	2	0		2021			R03	small molecule drug				Boehringer Ingelheim
Sanofi-Aventis	Lovenox	Enoxaparin	3700	4552		22	15	-7	0	5,389,618	2012.01.01			B01 (antithrombotic)	small molecule drug (heparin)				Sanofi-Aventis
Novo Nordisk	Novolog	Insulin	3585	2954		23	28	5	0	5,866,538	2017			A10 (Diabetes)	protein (endocrine)				Novo Nordisk
Eisai	Aricept	Donepezil	3500	4013		24	17	-7	0		2010			N06 (Psychoanaleptic)	small molecule drug				Eisai
Eli Lilly	Cymbalta	Duloxetine	3460	3317		25	26	1	0		2013			N06 (Psychoanaleptic)	small molecule drug	blocks Serotonin reuptake			Eli Lilly
Amgen	Enbrel	Etanercept	3274	5863		26	6	-20	0		2012.10.23	2023		L04 (Immunosuppressant)	protein (mAb)	TNF			Amgen
Pfizer	Lyrica	Pregabalin	3100	2840		27	29	2	0	5,563,175	2013			N03 (Antiepileptic)	small molecule drug				Pfizer
Gilead Sciences	Atripla	Tenofovir & Emtricitabine & Efavirenz	2926	2414		28	37	9	0		2021			J05 (Antiviral)	small molecule drug (combination)	HIV reverse transcriptase inhibition			Gilead Sciences
Teva Pharmaceuticals	Copaxone	Glatiramer acetate	2900	2432		29	36	7	0	5,981,589	2014			L03 (Immunostimulant)	small molecule drug				Teva Pharmaceuticals
Sanofi-Aventis	Taxotere	Docetaxel	2800	2689		30	31	1	0	4,814,470	2010			L01 (Antineoplastic)	small molecule drug				Sanofi-Aventis
Gilead Sciences	Truvada	Tenofovir & Emtricitabine	2650	2476		31	35	4	0	5,922,695	2021	2018		J05 (Antiviral)	small molecule drug (combination)	HIV reverse transcriptase inhibitor (nucleoside analogs)			Gilead Sciences
Daiichi Sankyo	Benicar	Olmesartan	2600	1533		32	65	33	0		2016								Daiichi Sankyo
Amgen	Aranesp	Epoetin alfa	2500	2752		33	30	-3	0		2014			B03 (Antianemic)	protein (erythropoietin)				Amgen
Merck & Co.	Januvia	Sitagliptin	2400	1893		34	51	17	0		2017								Merck & Co.
Forest Laboratories	Lexapro (US), Cipralex (EU)	Escitalopram	2300	2655		35	32	-3	0	6,916,941	2012.03.01			N06 (Psychoanaleptic)	small molecule drug (enantiomer)				Forest Laboratories
Eli Lilly	Alimta		2210	1495		36	70	34	0		2016	2022							Eli Lilly
Merck KGaA	Rebif		2200	1837		37	54	17	0						protein (interferon)		MS		Merck KGaA
Novo Nordisk	Novorapid	Insulin	2100	2100		38	46	8	0					A10 (Diabetes)	protein (insulin)				Novo Nordisk
Eli Lilly	Humalog	insulin	2050	1538		39	63	24	0		2013				protein (hormone)		endocrine / hormone		Eli Lilly
Pfizer	Viagra	Sildenafil	1928	1892		40	52	12	0	5,250,534	2012.01.01			G04BE (erectile dysfunction)	small molecule drug				Pfizer
Astellas Pharma	Prograf	Tacrolimus	1900	2018		41	48	7	0										Astellas Pharma
Pfizer	Xalatan/Xalacom		1749	1737		42	57	15	0		2011.01.01								Pfizer
Pfizer	Effexor	Venlafaxine	1718	3358		43	25	-18	0	6,274,171	2008			N06 (Psychoanaleptic)	small molecule drug (racemate)				Pfizer
Eli Lilly	Cialis		1700	1599		44	60	16	0		2017								Eli Lilly
Baxter International	Advate		1700			44
Abbott Laboratories	Trilipix / TriCor	Fenofibrate	1600	1594		46	61	15	0										Abbott Laboratories
Bayer	Betaferon		1600	1515		46	67	21	0										Bayer
Hoffmann-La Roche	Lucentis	Ranibizumab	1533	2163		48	44	-4	0					S01 (Ophthalmological)	protein (mAb)	VEGF receptor			Hoffmann-La Roche
Novartis	Zometa	Zoledronic acid	1511	1811		49	55	6	0	4,939,130	2012.01.01			M05					Novartis
Johnson & Johnson	Risperdal	Risperidone	1500	2297		50	43	-7	0					N05 (Psycholeptic)	small molecule drug				Johnson & Johnson
Lundbeck	Cipralex (EU), Lexapro (US)	Escitalopram	1500	987		50	109	59	0	RE34712	2011.03.01			N06 (Psychoanaleptic)	small molecule drug				Lundbeck
Abbott Laboratories	Kaletra		1300	1053		52	103	51	0										Abbott Laboratories
GlaxoSmithKline	Flixotide		1200	1330		53	81	28	0										GlaxoSmithKline
Pfizer	Zyvox		1176	1141		54	96	42	0		2015								Pfizer
Eli Lilly	Gemzar		1150	1292		55	86	31	0		2010	2013							Eli Lilly
Eli Lilly	Evista		1020	1063		56	100	44	0										Eli Lilly
Pfizer	Detrusitol/Detrol	Tolterodine	1013	1154		57	95	38	0	5,382,600	2012.01.01			G04 (Urological)	small molecule drug				Pfizer
Otsuka Pharmaceutical	Abilify	Aripiprazole		4657			14			5,006,528	2014			N05 (Psycholeptic)	small molecule drug				Otsuka Pharmaceutical
Takeda Pharmaceuticals	Takepron/Prevacid	Lansoprazole		3778			21				2009			A02 (Antacid)	small molecule drug	H+/K+-ATPase inhibitor (gastric)			Takeda Pharmaceuticals
Amgen	Epogen	Epoetin alfa		3099			27				2013			B03 (Antianemic)	protein (erythropoietin)				Amgen
GlaxoSmithKline	Valtrex	Valaciclovir		2510			34			4,957,924	2009			J05 (Antiviral)	small molecule drug	DNA polymerase			GlaxoSmithKline
Merck & Co.	Zetia	Ezetimibe		2397			38							C10	small molecule drug	cholesterol absorption inhibition (semi unknown function)			Merck & Co.
Pfizer	Celebrex	Celecoxib		2383			39			5,466,823	2014			L01 (Antineoplastic)	small molecule drug				Pfizer
AstraZeneca	Symbicort	Budesonide & Formoterol Fumarate		2353			40							R03	small molecule drug (combination)				AstraZeneca
Eisai	Pariet	Rabeprazole		2349			41							A02 (Antacid)	small molecule drug				Eisai
Merck & Co.	Vytorin	Ezetimibe & simvastatin		2315			42							C10	small molecule drug (combination)	HMG CoA reductase inhibitor			Merck & Co.
Merck & Co.	Cozaar	Losartan		2135			45			5,210,079	2010			C09	small molecule drug				Merck & Co.
Biogen Idec	Avonex	Interferon beta-1a		2100			46							L03 (Immunostimulant)	protein (interferon)		immunosuppresant (MS)		Biogen Idec
Pfizer	Norvasc	Amlodipine		1973			49								small molecule drug				Pfizer
AstraZeneca	Arimidex	Anastrozole		1922			50												AstraZeneca
Johnson & Johnson	One Touch Ultra			1840			53												Johnson & Johnson
Johnson & Johnson	Levaquin	Levofloxacin		1743			56				2010								Johnson & Johnson
Takeda Pharmaceuticals	Blopress	Candesartan		1705			58												Takeda Pharmaceuticals
Hoffmann-La Roche	Tamiflu			1606			59				2016	2016							Hoffmann-La Roche
Merck & Co.	Hyzaar			1592			62												Merck & Co.
Sanofi-Aventis	Eloxatine			1538			63												Sanofi-Aventis
Merck & Co.	Nasonex			1517			66												Merck & Co.
Hoffmann-La Roche	Cellcept			1505			68												Hoffmann-La Roche
AstraZeneca	Pulmicort			1505			68												AstraZeneca
Sanofi-Aventis	Stilnox			1483			71												Sanofi-Aventis
Hoffmann-La Roche	Neorecormon			1482			72												Hoffmann-La Roche
Procter & Gamble	Actonel	Risedronate		1472			73												Procter & Gamble
Johnson & Johnson	Concerta	Epoetin alfa		1463			74							B03 (Antianemic)		erythropoietin	growth factor		Johnson & Johnson
Boehringer Ingelheim	Micardis			1422			75												Boehringer Ingelheim
UCB	Keppra			1406			76			4,943,639	2008				small molecule drug	unknown function	anticonvulsant/antiepileptic		UCB
Eli Lilly	Erbitux	Cetuximab		1398			77								protein (mAb)	EGFR inhibitor	anticancer (colorectal)		Eli Lilly
Johnson & Johnson	Topamax			1375			78												Johnson & Johnson
Bristol Myers Squibb	Reyataz	Atazanavir		1338			79												Bristol Myers Squibb
AstraZeneca	Synagis	Palivizumab		1337			80								protein (mAb)	respiratory syncytial virus			AstraZeneca
Nycomed	Pantozol			1324			82								small molecule drug	H+/K+-ATPase inhibitor (gastric)			Nycomed
Novartis	Voltaren			1319			84												Novartis
Merck & Co.	Varivax			1300			85												Merck & Co.
Novo Nordisk	Novomix			1257			87												Novo Nordisk
Novartis	Femara			1238			88												Novartis
Johnson & Johnson	Velcade			1237			89												Johnson & Johnson
Boehringer Ingelheim	Sifrol			1232			90												Boehringer Ingelheim
Pfizer	Prevnar			1207			91												Pfizer
Hoffmann-La Roche	Pegasys			1189			92												Hoffmann-La Roche
Pfizer	Tazocin			1186			93												Pfizer
Hoffmann-La Roche	Bonviva			1161			94												Hoffmann-La Roche
Forest Laboratories	Namenda			1140			97												Forest Laboratories
Hoffmann-La Roche	Tarceva			1081			98												Hoffmann-La Roche
Hoffmann-La Roche	Xeloda			1079			99												Hoffmann-La Roche
Shire plc	Adderall			1062			101												Shire plc
Endo	Lidoderm			1062			101												Endo
Novartis	Sandostatin			1051			104												Novartis
Cephalon	Provigil			1021			105				2015				small molecule drug				Cephalon
Novo Nordisk	Levemir			1021			105												Novo Nordisk
Pfizer	Zeldox/Geodon			1002			107												Pfizer
GlaxoSmithKline	Augmentin			992			108												GlaxoSmithKline
CSL	Gardasil			972			110												CSL
Abbott Laboratories	Niaspan			964			111												Abbott Laboratories
Pfizer	Sutent			964			111												Pfizer
AstraZeneca	Zoladex			962			113												AstraZeneca
Merck & Co.	Temodal M-Co			958			114												Merck & Co.
Takeda Pharmaceuticals	Enantone			957			115												Takeda Pharmaceuticals
Johnson & Johnson	Duragesic	Fentanyl		951			116										analgesic		Johnson & Johnson
GlaxoSmithKline	Lamictal			950			117												GlaxoSmithKline
Novo Nordisk	Novoseven	Factor VII		938			118			4,382,083, 4,456,591, 4,479,938, 5,180,583	2010						haemostasis		Novo Nordisk
Boehringer Ingelheim	Combivent			938			118												Boehringer Ingelheim
Teva Pharmaceuticals	Salamol			936			120												Teva Pharmaceuticals
Baxter International	Recombinate	octocog alfa		935			121										blood coagulation		Baxter International
Novartis	Exelon			933			122												Novartis
AstraZeneca	Atacand			921			123												AstraZeneca
Astellas Pharma	Vesicare			904			124												Astellas Pharma
AstraZeneca	Losec			895			125												AstraZeneca
GE Healthcare	Omnipaque	Iohexol		889			126												GE Healthcare
Bayer	Yaz	Drospirenone & Ethinylestradiol		885			127								small molecule drugs (progestogen+estrogen)				Bayer
Procter & Gamble	Asacol	Mesalazine		811			128												Procter & Gamble
Bayer	Yasmin	Drospirenone & Ethinylestradiol		766			129								small molecule drugs (progestogen+estrogen)	granulocytes	immunostimulant		Bayer
Eli Lilly	Byetta	Exenatide		758			130				2017				protein (endocrine)	GLP-1 analog			Eli Lilly
AstraZeneca	Betaloc	Metroprolol		750			131												AstraZeneca
Biogen Idec	Tysabri	Natalizumab		714			132								protein				Biogen Idec
Celgene	Revlimid			703			133			5,635,517	2019				small molecule drug				Celgene
Novo Nordisk	Norditropin	GH1		675			134								protein (hormone)		hormone		Novo Nordisk
Sanofi-Aventis	Telfast	Fexofenadine		671			135				2014								Sanofi-Aventis
Hoffmann-La Roche	Xolair	Omalizumab		632			136								protein (mAb)	IgE			Hoffmann-La Roche
Actelion	Tracleer			614			137			5,292,740	2015				small molecule drug	endothelin receptor antagonist	pulmonary artery hypertension		Actelion
Eli Lilly	Prozac	Fluoxetine									2001				small molecule drug		antidepressant		Eli Lilly
Allergan	Botox	Botulinum toxin												M03	protein				Allergan
Novo Nordisk	Novolin	insulin												A10 (Diabetes)	protein (endocrine)		diabetes		Novo Nordisk